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NASA Spaceline Current Awareness List #845 19 April 2019 (Space Life Science Research Results) - Space Ref

Status Report From: Spaceline
Posted: Friday, April 19, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

 

Papers deriving from NASA support:

 

1

Checinska Sielaff A, Urbaniak C, Mohan GBM, Stepanov VG, Tran Q, Wood JM, Minich J, McDonald D, Mayer T, Knight R, Karouia F, Fox GE, Venkateswaran K.

Characterization of the total and viable bacterial and fungal communities associated with the International Space Station surfaces.

Microbiome. 2019 Apr 8;7(1):50.

https://www.ncbi.nlm.nih.gov/pubmed/30955503

PIs: K. Venkateswaran; C. Urbaniak, NASA Postdoctoral Fellowship Program

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 9.133

Funding: "This research was funded by a 2012 Space Biology NNH12ZTT001N grant nos. 19-12829-26 under Task Order NNN13D111T award to KV, which also funded post-doctoral fellowship for ACS and GBMM. Subcontracts to GF and RK were given through grant no. 19-12829-26. Funding for CU was supported by the NASA Postdoctoral Program."

 

2

Ronca AE, Moyer EL, Talyansky Y, Lowe M, Padmanabhan S, Choi S, Gong C, Cadena SM, Stodieck L, Globus RK.

Behavior of mice aboard the International Space Station.

Sci Rep. 2019 Apr 11;9(1):4717.

https://www.ncbi.nlm.nih.gov/pubmed/30976012

Note: ISS results. There is an accompanying video of the mice aboard the ISS at https://www.youtube.com/watch?v=q7lgj3aZ8dU . This article may be obtained online without charge. 

Journal Impact Factor: 4.122

Funding: "Funding was provided by the NASA Ames Research Center Space Biology Program, Rodent Research Project, and Center Directors Fund."

 

3

Dionisio-Santos DA, Olschowka JA, O'Banion MK.

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease.

J Neuroinflammation. 2019 Apr 5;16(1):74. Review.

https://www.ncbi.nlm.nih.gov/pubmed/30953557

PI: M.K. O'Banion

Note: This article may be obtained online without charge.

Journal Impact Factor: 5.193

Funding: "DADS is a student in the University of Rochester Medical Scientist Training Program (T32 GM007536) and is currently supported by The University of Rochester Toxicology Training Grant (T32 ES7026) MKO and JAO receive research support from the National Institutes of Health (R01 AG30149) and the National Aeronautics and Space Administration (NNX16AE07G)."

 

4

Lawler JM, Garcia-Villatoro EL, Guzzoni V, Hord JM, Botchlett R, Holly D, Lawler MS, Janini Gomes M, Ryan P, Rodriguez D, Kuczmarski JM, Fluckey JD, Talcott S.

Effect of combined fish oil & curcumin on murine skeletal muscle morphology and stress response proteins during mechanical unloading.

Nutr Res. 2019 Jan 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30954343

PIs: J.M. Lawler; J.M. Kuczmarski, NSBRI Postdoctoral Fellowship Program

Note: Hindlimb unloading study.

Journal Impact Factor: 2.707

Funding: "Funding for this study was provided by support from the NASA Space Biology program (NNX13AE45G) (JML), National Space Biomedical Research Institute through NCC 9-58 (JML, JMK), NIH (AR054084) (JML), and the Huffines Institute for Sports Medicine (JML), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES (VG). Confocal/multiphoton microscopy was performed in the Texas A&M College of Veterinary Medical and Biomedical Sciences Image Analysis Laboratory, supported with funding from NIH NCRR Shared Instrumentation Grant (1 S10 RR22532-01)."

 

5

Mortreux M, Riveros D, Bouxsein ML, Rutkove SB.

Mimicking a space mission to Mars using hindlimb unloading and partial weight bearing in rats.

J Vis Exp. 2019 Apr 4(146):e59327.

https://www.jove.com/video/59327/mimicking-space-mission-to-mars-using-hindlimb-unloading-partial

PI: S.B. Rutkove

Note: Hindlimb unloading study; a pelvic harness was used for the partial weight-bearing study.

Journal Impact Factor: 1.184

Funding: "This work was supported by the National Aeronautics and Space Administration (NASA: NNX16AL36G)."

 

6

Tang S, Liu B, Liu M, Li Z, Liu J, Wang H, Wang J, Oh YT, Shen L, Wang Y.

Ionizing radiation-induced growth in soft agar is associated with miR-21 upregulation in wild-type and DNA double strand break repair deficient cells.

DNA Repair (Amst). 2019 Mar 23;78:37-44.

https://www.ncbi.nlm.nih.gov/pubmed/30954901

PIs: Y. Wang/H. Wang/NSCOR

Journal Impact Factor: 4.461

Funding: "This work was supported by grants from US National Institutes of Health (CA186129 and CA185882 to Y.W., and P30CA138292 to Winship Cancer Institute), and the National Aeronautics and Space Administration, (NNX11AC30G to Y.W.)."

 

7

Robinson S, Granata L, Hienz RD, Davis CM.

Temporary inactivation of the medial prefrontal cortex impairs the formation, but not the retrieval of social odor recognition memory in rats.

Neurobiol Learn Mem. 2019 Apr 3;161:115-21.

https://www.ncbi.nlm.nih.gov/pubmed/30953696

PI: C.M. Davis

Journal Impact Factor: 3.244

Funding: "This research is supported by: NASA NNX15AC71G (CMD) & NASA 80NSSC18K1080 (CMD)."

 

8

Flynn-Evans EE, Ahmed O, Berneking M, Collen JF, Kancherla BS, Peters BR, Rishi MA, Sullivan SS, Upender R, Gurubhagavatula I.

Industrial regulation of fatigue: Lessons learned from aviation.

J Clin Sleep Med. 2019 Apr 2. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30952229 

Note: The authors examine the relationship between fatigue, circadian rhythm, and work hour restrictions. The discussion is based on the report of the National Transportation Safety Board (NTSB) "Taxiway Overflight, Air Canada Flight 759, Airbus A320-211, C-FKCK, San Francisco, CA, July 7, 2017." (Washington, DC: NTSB, 2018.)

Journal Impact Factor: 3.396

Funding: No funding cited. E.E. Flynn-Evans is affiliated with NASA Ames Research Center.

 

9

McIntyre ABR, Ounit R, Afshinnekoo E, Prill RJ, Henaff E, Alexander N, Minot SS, Danko D, Foox J, Ahsanuddin S, Tighe S, Hasan NA, Subramanian P, Moffat K, Levy S, Lonardi S, Greenfield N, Colwell RR, Rosen GL, Mason CE. 

Correction to: Comprehensive benchmarking and ensemble approaches for metagenomic classifiers.

Genome Biol. 2019 Apr 5;20(1):72.

https://www.ncbi.nlm.nih.gov/pubmed/30953547

PI: C.E. Mason

Note: The authors present two corrections to the original article. The original article was cited in SPACELINE Current Awareness List #768, 6 Oct 2017. https://www.ncbi.nlm.nih.gov/pubmed/28934964. Both the original article and correction may be obtained online without charge.

Journal Impact Factor: 13.214

Funding: From the original paper: "We would also like to thank the Epigenomics Core Facility at Weill Cornell Medicine as well as the Starr Cancer Consortium grants (I9-A9-071) and funding from the Irma T. Hirschl and Monique Weill-Caulier Charitable Trusts, Bert L. and N. Kuggie Vallee Foundation, the WorldQuant Foundation, The Pershing Square Sohn Cancer Research Alliance, NASA (NNX14AH50G, NNX17AB26G), the National Institutes of Health (R25EB020393, R01AI125416, R01ES021006), the National Science Foundation (grant no. 1120622), the Bill and Melinda Gates Foundation (OPP1151054), and the Alfred P. Sloan Foundation (G-2015-13964). Support was also provided by the Tri-Institutional Training Program in Computational Biology and Medicine and the Clinical and Translational Science Center (Jeff Zhu)."

_______________________________________________________

 

 

Other papers of interest:

 

1

Krüger M, Pietsch J, Bauer J, Kopp S, Carvalho DTO, Baatout S, Moreels M, Melnik D, Wehland M, Egli M, Jayashree S, Kobberø SD, Corydon TJ, Nebuloni S, Gass S, Evert M, Infanger M, Grimm D. 

Growth of endothelial cells in space and in simulated microgravity - A comparison on the secretory level.

Cell Physiol Biochem. 2019;52(5):1039-60.

https://www.ncbi.nlm.nih.gov/pubmed/30977987

Note: ISS results; a Random Positioning Machine was used for ground-based experiments. This article may be obtained online without charge.

 

2

De Middeleer G, Leys N, Sas B, De Saeger S.

Fungi and mycotoxins in space—A review.

Astrobiology. 2019 Apr 11. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30973270

Note: Results from ISS and Mir are discussed.

 

3

Gruber M, Kramer A, Mulder E, Rittweger J.

The importance of impact loading and the stretch shortening cycle for spaceflight countermeasures.

Front Physiol. 2019 Mar 22;10:311. Review.

https://www.ncbi.nlm.nih.gov/pubmed/30967797

Note: ISS results and bed rest studies are discussed. This article may be obtained online without charge.

 

4

Haase CG, Fuller NW, Hranac CR, Hayman DTS, Olson SH, Plowright RK, McGuire LP.

Bats are not squirrels: Revisiting the cost of cooling in hibernating mammals.

J Therm Biol. 2019 Apr;81:185-93.

https://www.ncbi.nlm.nih.gov/pubmed/30975417

 

5

Regan MD, Chiang E, Martin SL, Porter WP, Assadi-Porter FM, Carey HV.

Shifts in metabolic fuel use coincide with maximal rates of ventilation and body surface rewarming in an arousing hibernator.

Am J Physiol Regul Integr Comp Physiol. 2019 Apr 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30969844

 

6

Tomilovskaya E, Shigueva T, Sayenko D, Rukavishnikov I, Kozlovskaya I.

Dry immersion as a ground-based model of microgravity physiological effects.

Front Physiol. 2019 Mar 27;10:284. Review.

https://www.ncbi.nlm.nih.gov/pubmed/30971938

Note: Dry immersion studies are discussed. This article may be obtained online without charge.

 

7

Kravchenko IV, Furalyov VA, Popov VO.

Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy.

Biochem Biophys Rep. 2019 Jul;18:100627. Epub 2019 Mar 21.

https://www.ncbi.nlm.nih.gov/pubmed/30957033

Note: This article may be obtained online without charge.

 

8

Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP.

Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women.

FASEB J. 2019 Apr 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30970218

Note: Single leg immobilization (via casting) was used.

 

9

Reidy PT, McKenzie AI, Mahmassani ZS, Petrocelli JJ, Nelson DB, Lindsay CC, Gardner JE, Morrow VR, Keefe AC, Huffaker TB, Stoddard GJ, Kardon G, O'Connell RM, Drummond MJ.

Aging impairs mouse skeletal muscle macrophage polarization and muscle-specific abundance during recovery from disuse.

Am J Physiol Endocrinol Metab. 2019 Apr 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30964703

Note: Hindlimb unloading study.

 

10

Jacome-Galarza CE, Percin GI, Muller JT, Mass E, Lazarov T, Eitler J, Rauner M, Yadav VK, Crozet L, Bohm M, Loyher PL, Karsenty G, Waskow C, Geissmann F.

Developmental origin, functional maintenance and genetic rescue of osteoclasts.

Nature. 2019 Apr 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30971820

 

11

Prasad J, Goyal A.

An invertible mathematical model of cortical bone's adaptation to mechanical loading.

Sci Rep. 2019 Apr 10;9(1):5890.

https://www.ncbi.nlm.nih.gov/pubmed/30971812

Note: This article may be obtained online without charge.

 

12

Xu L, Shao H, Ma YH, You L.

OCY454 osteocytes as an in vitro cell model for bone remodelling under mechanical loading.

J Orthop Res. 2019 Apr 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30977540

 

13

Khan SI, Della Santina CC, Migliaccio AA.

Angular vestibulo-ocular reflex responses in Otop1 mice. I. Otolith sensor input is essential for gravity context-specific adaptation.

J Neurophysiol. 2019 Apr 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30969887

 

14

Khan SI, Della Santina CC, Migliaccio AA.

Angular vestibulo-ocular reflex responses in Otop1 mice. II. Otolith sensor input improves compensation after unilateral labyrinthectomy.

J Neurophysiol. 2019 Apr 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30969882

 

15

Agrawal A, Pacheco-Hernandez A, Moscote-Salazar LR.

Letter: Neurosurgery and manned spaceflight.

Neurosurgery. 2019 Apr 8. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30957146

Note: The authors comment on: Panesar SS, Fernandez-Miranda JC, Kliot M, Ashkan K. Neurosurgery and manned spaceflight. Neurosurgery. 2018 Nov 8. [Epub ahead of print] Review. https://www.ncbi.nlm.nih.gov/pubmed/30407580. The original article appeared in SPACELINE Current Awareness List #824, 16 Nov 2018.

 

16

Faraoni P, Sereni E, Gnerucci A, Cialdai F, Monici M, Ranaldi F.

Glyoxylate cycle activity in Pinus pinea seeds during germination in altered gravity conditions.

Plant Physiol Biochem. 2019 Jun;139:389-94. Epub 2019 Apr 3.

https://www.ncbi.nlm.nih.gov/pubmed/30959447

Note: A Random Positioning Machine and a centrifuge were used.

 

17

Ge L, Chen R.

NEGATIVE GRAVITROPIC RESPONSE OF ROOTS directs auxin flow to control root gravitropism.

Plant Cell Environ. 2019 Apr 10. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30968964

Note: Seeds were grown in vertically-oriented culture media.

 

18

Lee MK, Lyu JI, Hong MJ, Kim DG, Kim JM, Kim JB, Eom SH, Ha BK, Kwon SJ.

Utility of TRAP markers to determine indel mutation frequencies induced by gamma-ray irradiation of faba bean (Vicia faba L.) seeds.

Int J Radiat Biol. 2019 Apr 9. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/30964373

 

19

Nakamura M, Nishimura T, Morita MT.

Input and signal conversion of gravity in plant gravitropism.

J Exp Bot. 2019 Apr 12. [Epub ahead of print] Review.

https://www.ncbi.nlm.nih.gov/pubmed/30976802

 

20

Mazur LM, Mosaly PR, Moore C, Marks L.

Association of the usability of electronic health records with cognitive workload and performance levels among physicians.

JAMA Netw Open. 2019 Apr 5;2(4):e191709.

https://www.ncbi.nlm.nih.gov/pubmed/30951160

Note: The NASA Task Load Index was used. This article may be obtained online without charge.

 

21

Szocik K, Ed.

The Human Factor in a Mission to Mars: An Interdisciplinary Approach.

Cham, Switzerland: Springer; 2019.  266 p.

https://www.springer.com/us/book/9783030020583 

Note: The 14 chapters are: Martian environmental psychology: The choice architecture of a Mars mission and colony; Program planning for a Mars hardship post: Social, psychological, and spiritual services; Enabling and enhancing human health and performance for Mars colonies: Smart spacecraft and smart habitats (chapter by former NASA HRP Chief Scientist Mark Shelhamer); The impact of space weather on human missions to Mars: The need for good engineering and good forecasts; Mars and beyond: The feasibility of living in the solar system; Human extremophiles: Mars as a camera obscura of the extraterrestrial scientific culture; Colonising Mars: A time frame for ethical questioning; Can deep altruism sustain space settlement; Interplanetary sustainability: Mars as a means of a long-term sustainable development of human kind in the solar system; Mars environmental protection: An application on the 1/8 principle; Science and ethics in the exploration of Mars; Ethics for an uninhabited planet; Religion for a spatial colony: Raising the right questions; and Human place in the outer space: Skeptical remarks.

// end //

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